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Thermo Scientific Chemicals
2'-Deoxyuridine-5'-monophosphate disodium salt, 99%
CAS: 42155-08-8 | C9H13N2Na2O8P | 354.162 g/mol
化学物質識別子
CAS42155-08-8
IUPAC Name{[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
Molecular FormulaC9H13N2O8P
InChI KeyJSRLJPSBLDHEIO-SHYZEUOFSA-N
SMILESO[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White
FormPowder or crystals or crystalline powder
Purity≥98.5% (HPLC)
Water Content≤25.0%
2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
Solubility
Soluble in water.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
Solubility
Soluble in water.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Ruth L. Saxl.; James Reston.; Zhe Nie.; Thomas I. Kalman.; Frank Maley. Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2‘-deoxyuridine 5‘-Monophosphate. Biochemistry. 2003, 42 (15), 4544-4551.
- Mikhail V. Rekharsky.; Asao Nakamura.; Guy A. Hembury.; Yoshihisa Inoue. Thermodynamic Study of the Discrimination between Uridine and Thymidine Derivatives by Hydrophobic, Stacking, and Intercalating Interactions. Bulletin of the Chemical Society of Japan. 2001, 74 (3), 449-457.