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Thermo Scientific Chemicals
4,5-Dicyanoimidazole, 98+%
CAS: 1122-28-7 | C5H2N4 | 118.10 g/mol
化学物質識別子
CAS1122-28-7
IUPAC Name1H-imidazole-4,5-dicarbonitrile
Molecular FormulaC5H2N4
InChI KeyXGDRLCRGKUCBQL-UHFFFAOYSA-N
SMILESN#CC1=C(N=CN1)C#N
さらに表示
仕様
スペックシート
スペックシートAssay from Suppliers CofA≥97.5% (U.S. specification)
Appearance (Color)White to cream to dark brown to pale brown
FormCrystals or powder or crystalline powder or fused solid
Assay (HPLC)≥97.5% (non-U.S. specification)
CommentSpecification differs for U.S. and non-U.S. material where indicated
4,5-Dicyanoimidazole is used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. It is often used as an alternative to tetrazole.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4,5-Dicyanoimidazole is used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. It is often used as an alternative to tetrazole.
Solubility
Soluble in Acetonitrile: 1.8g/10ml, DMSO, Methanol.
Notes
Store in a cool, dry conditions in well sealed container. Incompatible with oxidizing agents.
4,5-Dicyanoimidazole is used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. It is often used as an alternative to tetrazole.
Solubility
Soluble in Acetonitrile: 1.8g/10ml, DMSO, Methanol.
Notes
Store in a cool, dry conditions in well sealed container. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Chandra Vargeese; Jeff Carter; John Yegge; Shira Krivjansky; Alecia Settle; Eric Kropp; Kent Peterson and Wolfgang Pieken. Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis. Nucl. Acids Res.1998, 26, (4), 1046-1050.
- Paul G. Apen; Paul G. Rasmussen. Synthesis and properties of new derivatives of 4,5-dicyanoimidazole and 4,4',5,5'-tetracyano-2,2'-biimidazole. J. Am. Chem. Soc.1991, 113, (16), 6178-6187.