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Invitrogen
GABRR1 Polyclonal Antibody
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FIGURE: 1 / 1
GABRR1 Antibody (PA5-91876) in WB
Western blot analysis of GABRR1 in extracts of various cell lines. Samples were incubated with GABRR1 Polyclonal antibody (Product # PA5-91876) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-91876
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human GABRR1 (NP_0020332)
Conjugate
Form
Liquid
Concentration
1.95 mg/mL
Amount
195 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLAVPNMRFG IFLLWWGWVL ATESRMHWPG REVHEMSKKG RPQRQRREVH EDAHKQVSPI LRRSPDITKS PLTKSEQLLR; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels; however, they are structurally and functionally distinct. GABAC receptors (GABAC Rr) mediate rapid inhibitory neurotransmission in retina. Three human genes, r1 (GABRR1), r2 (GABRR2) and r3 (GABRR3), encode the three polypeptides that comprise this receptor. GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but GABRR3 maps to chromosome 3q11-q13.3. The r polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family. The expression of GABAC Rr subunits is not restricted to the retina, but significant expression can also be detected in many other brain regions, especially in those belonging to the visual pathways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1); GABA(A) receptor subunit rho-1; GABA(A) receptor, rho 1; GABA(C) receptor; GABA(C) rho1; GABAAR subunit rho-1; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, rho-1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor subunit rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; gamma-aminobutyric acid A receptor, rho 1; Gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho1 subunit; unnamed protein product
Gene Aliases: GABA-C; GABRR1
UniProt ID: (Human) P24046, (Mouse) P56475, (Rat) P50572
Entrez Gene ID: (Human) 2569, (Mouse) 14408, (Rat) 29694
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA receptor activity
protein domain specific binding
GABA-gated chloride ion channel activity
identical protein binding
macromolecular complex binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
protein homodimerization activity
protein heterodimerization activity
protein binding
ligand-gated ion channel
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
ion transmembrane transport
modulation of synaptic transmission
synaptic transmission, GABAergic
regulation of presynaptic membrane potential
chloride transmembrane transport
transport
signal transduction
visual perception
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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