Vanquish™ Core Binary HPLC System - FAQs

How many samples can the Vanquish Core HPLC System hold, and can we add a feeder for long, unattended sequences?

The autosampler holds 4 sample plates or vial trays (216 2 mL vials). You can expand to 8,832 samples (23 plates) using the Vanquish Sample Hub module.

What pressure and flow window does the Vanquish Core HPLC System accommodate for our 4.6 mm columns and fast runs?

The platform delivers up to 700 bar (10,000 psi) and 10 mL/min with high flow/gradient precision via SmartFlow technology, ideal for typical analytical formats.

Is the Vanquish Core HPLC System easy to use?

Yes. The Thermo Scientific Vanquish Core HPLC System was built for routine labs that want reliability without a steep learning curve. It is built on the Vanquish platform with tool-free Thermo Scientific Viper fittings, System Health Monitoring, solvent level monitoring, touchscreen UI providing guided operation and maintenance videos so day-to-day operation stays simple and productive.

What software do Vanquish (U)HPLC systems use? Is it suited to regulated labs?

Thermo Scientific Vanquish (U)HPLC systems integrate with the Thermo Scientific Chromeleon Chromatography Data System (CDS), which provides instrument control, automation, data processing and compliance-oriented features and auditability. Vanquish (U)HPLC systems can also integrate seamlessly with a third party CDS, such as Empower, OpenLab or LabSolutions.

We have legacy HPLC methods. What tools are available to simplify transferring our methods to Vanquish HPLC systems?

Thermo Scientific Vanquish HPLC systems include tools to replicate method behavior, such as tunable gradient delay volume and multiple column heating modes that match existing conditions. They are expressly designed to simplify method transfer from other instruments.

I’m trying to choose the right Vanquish (U)HPLC system. How do Vanquish Core HPLC, Vanquish Flex UHPLC and Vanquish Neo UHPLC differ?

Think of the Thermo Scientific Vanquish Core HPLC for routine analytical work with straightforward gradients, the Thermo Scientific Vanquish Flex UHPLC for high-throughput and flexible method development (binary or quaternary mixing), and the Thermo Scientific Vanquish Neo UHPLC for low-flow LCMS (nano/capillary/micro). Vanquish Core HPLC goes to 700 bar (10,000 psi) with flows up to 10 mL/min; Vanquish Flex UHPLC to 1000 bar (15,000 psi) with up to 8 mL/min; Vanquish Neo UHPLC to 1500 bar (22,000 psi) and 1 nL/min–100 µL/min for ultrasensitive LCMS analysis.

What are the main differences between the iCAP PRO, iCAP PRO X, iCAP PRO XP, and iCAP PRO XPS models?

The main differences among the Thermo Scientific iCAP PRO models are based on their specific features and intended applications:

• iCAP PRO: For routine laboratory analysis with fast start-up, easy-to-use software, and robust performance. It simplifies analysis in laboratories performing standardized analysis for a low number of samples.
• iCAP PRO X: For high-matrix trace elemental analysis with sensitive multi-element detection, ideal for challenging samples. It helps laboratories with moderate throughput and established methods to improve performance and reliability.
• iCAP PRO XP: Flexibility for method optimization and achieves advanced performance using an enhanced ultraviolet (eUV) analysis mode, which measures the UV region of the spectrum with greater sensitivity. Fast data acquisition times allow for high throughput labs to stay competitive.
• iCAP PRO XPS: Exceptional throughput and versatility, meeting specific regulatory requirements with high-speed analysis and excellent stability. With short integration times and high flexibility, this system is appropriate for testing labs that require the high throughput and performance.