Cinchonidine, 98.5-101%

Name: Cinchonidine, 98.5-101%
SKU: 110331000

Cinchonidine, CAS # 485-71-2, is a naturally occurring alkaloid that may be used in asymmetric synthesis and exhibits anti-malarial activity | CAS: 485-71-2 | C19H22N2O | 294.40 g/mol

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数量:

25 g

100 g

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製品番号（カタログ番号） 110331000

価格（JPY）

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数量:

100 g

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化学物質識別子

CAS485-71-2

IUPAC Name{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)methanol

Molecular FormulaC19H22N2O

InChI KeyKMPWYEUPVWOPIM-UHFFFAOYNA-N

SMILESOC(C1CC2CCN1CC2C=C)C1=C2C=CC=CC2=NC=C1

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仕様

スペックシート

Titration with HClO498.5 to 101.0 % (On dried substance)

Appearance (Form)Crystalline powder

Melting point>=200°C

Specific optical rotation-105° to -115° (20°C, 589 nm) (c=1, EtOH)

Infrared spectrumConforms

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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Cinchonidine is an alkaloid naturally occurring in the bark of Cinchona strubs that has activity against Plasmodium spp
Cinchonidine is a diastereoisomer of cinchonine and can be used to promote chirality in asymmetric or enantioselective synthesis of organic compounds

Applications

Cinchonidine has been used as a starting material in the synthesis of anti-malarial cinchona alkaloid conjugates
Has been shown to potently induce γ-globin mRNA and fetal hemoglobin in erythroid progenitor cells and may be useful in preclinical studies of β-thalassemia

RUO – Research Use Only

General References:

Mishra, N.; Agrahari, A.K.; Bose, P.; Singh, S.K.; Singh, A.S.; Tiwari, V.K. Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors. Sci Rep. 2020, 10(1), 3586.
Zuccato, C.; Cosenza, L.C.; Zurlo, M.; Lampronti, I.; Borgatti, M.; Scapoli, C.; Gambari, R.; Finotti, A. Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production. Int J Mol Sci. 2021, 22(24), 13433.