Estrone, 99+%, Thermo Scientific Chemicals

Estrone, 99%, CAS#53-16-7, is one of the major mammalian estrogen, is a steroid and a sex hormone. It is synthetized from cholesterol and secreted mainly from the gonads. It also presents antineoplastic and bone density conservative activities.

製品番号（カタログ番号）	数量	パッケージ
117840250	25 g	Glass bottle

製品番号（カタログ番号） 117840250

価格（JPY）

パッケージ:

Glass bottle

一括またはカスタム形式をリクエストする

化学物質識別子

CAS53-16-7

IUPAC Name(3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one

Molecular FormulaC18H22O2

InChI KeyDNXHEGUUPJUMQT-CBZIJGRNSA-N

SMILESC[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CCC2=O

さらに表示

Equilenin and equilinPasses test

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Estrone is an aromatized C18 steroid considered one of the major mammalian estrogen and a sex hormone. It shows antineoplastic and bone density conservative activities.

• This compound can interact with estrogen receptors in target tissues to produce similar effects to estradiol. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes.

Applications

• Estrone has the ability to increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins.

• It can suppress the release of follicle-stimulating hormone and luteinizing hormone.

• This compound can be produced from androstenedione or testosterone via estradiol. In vivo, it can be generated mainly in the ovaries, placenta, and peripheral tissues (especially adipose tissue) through conversion of androstenedione. It may be metabolized to 16-α-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.

• It has been used as medium supplement for hormone-based degranulation studies of natural killer cells.

• It is used as medium component for monitoring fatty acid synthase activity in breast adenocarcinoma cell lines.

RUO – Research Use Only

General References:

Vardanyan, R.; Hruby, V. 28 - Female Sex Hormones. Synthesis of Essential Drugs. 2006, 365-379.
Macek Jilkova, Z.; Decaens, T.; Marlu, A.; Marche, H.; Jouvin-Marche, E.; Marche, P.N. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels. Mediators Inflamm. 2017, 2017, 3214917.