Melatonine, 99%

Name: Melatonine, 99%
SKU: 125362500

Melatonine, 99%, CAS # 73-31-4, is a hormone usually produced in the pineal gland and released into the blood.

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製品番号（カタログ番号） 125362500

価格（JPY）

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化学物質識別子

CAS73-31-4

IUPAC NameN-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Molecular FormulaC13H16N2O2

InChI KeyDRLFMBDRBRZALE-UHFFFAOYSA-N

SMILESCOC1=CC=C2NC=C(CCNC(C)=O)C2=C1

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仕様

スペックシート

Appearance (Color)White to cream to yellow

Infrared spectrumConforms

HPLC>=98.5 %

Heavy metals=<20 ppm

Melting point116°C to 120°C

さらに表示

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Melatonine is a hormone produced by the pineal gland that shows several biological activities, including the somnolence, sleep-wake cycle, circadian rhythm, stress response, aging, and immunity activities

• It shows antioxidant, autocoid, paracoid, hormonal, anti- inflammatory and anti-apoptotic activities

Applications

• Melatonin shows neurohormonal activity and can upregulate antioxidant enzymes and inhibit rat NOS1

• Melatonin has been reported to be an activator of MEL-1A-R and MEL-1B-R

• The production and secretion of melatonine are dependent on beta-adrenergic receptor function

• During melatonine synthesis, the essential amino acid L-tryptophan is used as a precursor

• This compound inhibits apoptosis in immune cells and neurons, and enhances apoptotic cell death of cancer cells

• It can inhibit proliferation and metastasis of breast cancer cells by modulating Rho-associated kinase protein-1 expression

RUO – Research Use Only

Literature References

Borin, T.F.; Arbab, A.S.; Gelaleti, G.B.; Ferreira, L.C.; Moschetta, M.G.; Jardim-Perassi, B.V.; Iskander, A.S.; Varma, N.R.; Shankar, A.; Coimbra, V.B.; Fabri, V.A.; de Oliveira, J.G.; Zuccari, D.A. Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. J Pineal Res. 2016, 60, (1), 3-15.

Tan, D.X.; Manchester, L.C.; Hardeland, R.; Lopez-Burillo, S.; Mayo, J.C.; Sainz, R.M.; Reiter, R.J. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res. 2003, 34, (1), 75-78.

Dubocovich, M.L. Pharmacology and function of melatonin receptors. FASEB J. 1988, 2, (12), 2765-73. Reiter, R.J., et al. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann. N.Y. Acad. Sci. 2001, 939, 200-15.