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Thermo Scientific Chemicals
2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
2-Mercapto-1-methylimidazole, CAS # 60-56-0, also known as methimazole, is a thyroid hormone antagonist used to study the treatment of thyroid disorders.
化学物質識別子
CAS60-56-0
IUPAC Name1-methyl-2,3-dihydro-1H-imidazole-2-thione
Molecular FormulaC4H6N2S
InChI KeyPMRYVIKBURPHAH-UHFFFAOYSA-N
SMILESCN1C=CNC1=S
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仕様
スペックシート
スペックシートAppearance (Color)White to cream to yellow-brown
Titration with NaOH>=97.5 % (On dried substance)
Melting point140°C to 145°C
Loss on drying=<1 % (105°C, 2 hrs)
Infrared spectrumConforms
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• 2-Mercapto-1-methylimidazole, also known as methimazole, is an antithyroid medication
• Methimazole works by inhibiting the enzyme thyroid peroxidase (TPO), which is responsible for synthesizing the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the precursor thyroglobulin
Applications
• Methimazole has been used in laboratory settings to model olfactory epithelial degeneration
• May be used to study disruptions in iodide metabolism
• Methimazole has been used in Pharmacokinetics studies in the laboratory
RUO – Research Use Only
Literature references
Stanley, M.M.; Astwood, E.B. 1-Methyl-2-mercaptoimidazole; an antithyroid compound highly active in man. Endocrinology. 1949, 44(6), 588.
Ogawa, T.; Takezawa, K.; Shimizu, S.; Shimizu, T. Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage. Am J Rhinol Allergy. 2014, 28(2), e95-9.
Furman, B.L. in xPharm: The Comprehensive Pharmacology Reference. Methimazole. 2007 pp 1-4.