RNAi specificity: how big of an issue is it?
Authors:Samarsky DA, Welch PJ,
Journal:Pharmacogenomics
PubMed ID:15723598
RNAi techniques hold great promise for science,
from basic research all the way to human therapeutics,
and our understanding of the underlying
mechanisms have allowed us to design
better and more effective compounds. Fortunately,
much has also been learned about nonspecific
effects, such as off-target and stress
responses. These observations and discoveries
have led us to improved specificity ... More