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Thermo Scientific Chemicals
Yohimbine hydrochloride, 99%
Yohimbine hydrochloride, CAS # 65-19-0, is an α2-adrenergic receptor antagonist, which blocks the central α2-adrenegic receptors in the brain. | CAS: 65-19-0 | C21H27ClN2O3 | 390.91 g/mol
化学物質識別子
CAS65-19-0
IUPAC Namehydrogen methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-2(10),4,6,8-tetraene-19-carboxylate chloride
Molecular FormulaC21H27ClN2O3
InChI KeyPIPZGJSEDRMUAW-VJDCAHTMSA-N
SMILES[H+].[Cl-].COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCC4=C(NC5=CC=CC=C45)[C@@H]3C[C@H]12
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仕様
スペックシート
スペックシートAppearance (Color)White to light yellow
Appearance (Form)Powder
Infrared spectrumConforms
Titration with HClO4>=98.5 %
Specific optical rotation+99° to +105° (20°C, 589 nm) (c=1, H2O)
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Yohimbine hydrochloride is an indole alkaloid derived from the tree bark
- It is an antagonist of α2-adrenergic receptors in the brain, reducing the effects of xylazine, which is an α2-adrenergic agonist
Applications
- Yohimbine hydrochloride blocks the central α2-adrenegic receptors in the brain
- It can reduce or eradicate effects of xylazine, which is an α2-adrenergic agonist
- It can have an antidiuretic effect
RUO – Research Use Only
General References:
- Zhang, W. and Roomans, G.M. A yohimbine-dependent, UK14,304 induced ion transient in HT29 cells studied by X-ray microanalysis. Scanning microscopy, 1996, 10 (1), 293-299.
- Susan, X. Jiang et. al. Reversible inhibition of intracellular calcium influx through NMDA receptors by imidazoline I2receptor antagonists. European Journal of Pharmacology. 2010, 629,(1), 12-19.