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Thermo Scientific Chemicals
D(+)-Galactosamine Hydrochloride, 99%, Thermo Scientific Chemicals
D(+)-Galactosamine hydrochloride ((2R,3R,4R,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride), CAS # 1772-03-8, is the salt of the amino sugar that acts as an RNA synthesis inhibitor in hepatocytes.
化学物質識別子
CAS1772-03-8
IUPAC Namehydrogen (3R,4R,5R,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol chloride
Molecular FormulaC6H14ClNO5
InChI KeyQKPLRMLTKYXDST-BMZZJELJSA-N
SMILES[H+].[Cl-].N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O
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仕様
スペックシート
スペックシートWater=<1 % (K.F.)
Specific optical rotation+93° to +99° (20°C, 589 nm) (c=1, H2O)
Specific optical rotationafter 24 h
Residue after ignition=<1 %
Appearance (Color)White to off-white
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• D-Galactosamine is a pyranose amino sugar with hepatotoxic traits
• It acts as an RNA synthesis inhibitor in hepatocytes
• It promotes adherence of polymorphonuclear leukocytes to endothelial cells, increasing superoxide production
Applications
• D-Galactosamine can be used as a hepatotoxic in experimental in vitro models when in combination with LPS
• It is suitable for a range of biochemical laboratory applications
RUO – Research Use Only
General References:
- Kennedy, J.F. Selective detection and quantitative determination of the pentoses. 1970, Chromatographia 3, 316–319.
- Lloro, I.; Gonzalez, E.; Gutierrez-de Juan, V. et al. Non-invasive detection of drug toxicity in rats by solid-phase extraction and MALDI-TOF analysis of urine samples. Anal Bioanal Chem 2013, 405, 2311–2320.