Ouabain octahydrate, 96%

Name: Ouabain octahydrate, 96%
SKU: 161730010

Ouabain octahydrate, CAS # 11018-89-6, (synonym: gamma-Strophanthin), is a plant-derived organic compound that inhibits the Na+/K+ ATPase pump present in all animal cell membranes. | CAS: 11018-89-6 | C₂₉H₄₄O₁₂·₈H₂O | 728.78 g/mol

テクニカルサポートオーダーサポート

表示を変更

数量:

250 mg

1 g

5 g

25 g

パッケージ:

Glass bottle

Chem dex^TM Webアプリをお試しください

製品番号（カタログ番号） 161730010

価格（JPY）

見積もりを依頼する

数量:

1 g

パッケージ:

Glass bottle

一括またはカスタム形式をリクエストする

化学物質識別子

CAS11018-89-6

IUPAC Name4-[(1R,7S,9R,9bS,10R)-3a,5a,9,10-tetrahydroxy-9a-(hydroxymethyl)-11a-methyl-7-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2,5-dihydrofuran-2-one octahydrate

Molecular FormulaC29H60O20

InChI KeyTYBARJRCFHUHSN-HMNHGHQSSA-N

SMILESO.O.O.O.O.O.O.O.CC1OC(O[C@H]2C[C@@H](O)C3(CO)[C@H]4[C@H](O)CC5(C)[C@H](CCC5(O)C4CCC3(O)C2)C2=CC(=O)OC2)C(O)C(O)C1O

さらに表示

仕様

スペックシート

Appearance (Color)White to off-white

Appearance (Form)Crystalline powder

Infrared spectrumConforms

Solubility(1 % in water) Clear colorless

Specific optical rotation-30° to -33° (20°C, 589 nm) (c=1, H2O)

さらに表示

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Ouabain octahydrate is a water-soluble, light-sensitive powder that is stable at ambient temperatures
• It is a glycoside comprised of rhamnose and ouabagenin, and is derived from the ripe seeds of Strophanthus gratus and the bark of Acokanthera ouabaio

Applications

• Ouabain octahydrate works by binding the Na+/K+ ATPase pump, thus disrupting its function, and leading to an increase in intracellular Na+.
• The inhibitory action of ouabain octahydrate on the Na+/K+ pump in cardiac cells makes it a pharmaceutical cardioactive agent
• Ouabain octahydrate has also been found to induce cytotoxic effects through a steroidal signal transduction pathway, in laboratory preparations

RUO – Research Use Only

General References:

Gao J.; Wymore R.S.; Wang Y.; Gaudette G.R.; Krukenkamp I.B.; Cohen I.S.; Mathias R.T. Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol. 2002, 119(4), 297-312.
Hamlyn J. M.; Blaustein M.P.; Bova S.; DuCharme D.W.; Harris D.W.; Mandel F.; Mathews W.R.; Ludens J.H. Identification and characterization of an ouabain-like compound from human plasma. Proc Natl Acad Sci U S A. 1991, 15, 88(14), 6259-63.
Hamlyn J. M.; Laredo J.; Shah J. R.; Lu Z. R.; Hamilton B. P. 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. Ann N Y Acad Sci. 2003, 986, 685-93.
Kulikov, A.; Eva, A.; Kirch, U.; Boldyrev, A.; Scheiner-Bobis G. Ouabain activates signaling pathways associated with cell death in human neuroblastoma Biochim Biophys Acta 2007, 1768(7), 1691-702.