L(+)-Amethopterin hydrate, 99%
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L(+)-Amethopterin hydrate, 99%
L(+)-Amethopterin hydrate, 99%
L(+)-Amethopterin hydrate, 99%
Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, 99%

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol
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数量:
25 mg
100 mg
500 mg
パッケージ:
Glass Bottle
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製品番号（カタログ番号） 208105000
価格（JPY）
-
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数量:
500 mg
パッケージ:
Glass Bottle
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化学物質識別子
CAS133073-73-1
IUPAC Name(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Molecular FormulaC20H22N8O5
InChI KeyFBOZXECLQNJBKD-UGPWUYPHNA-N
SMILESCN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
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仕様Specification Sheetスペックシート
Infrared spectrumConforms
Specific optical rotationon anhydrous substance
Water=<13 % (K.F.)
Appearance (Color)Yellow to orange
HPLC>=98.5 %
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
  • It has tumoricidal activity

Applications

  • L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
  • It can be used in anti-tumor studies
  • It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
  • It can also inhibit production of pro-inflammatory cytokines
RUO – Research Use Only

General References:

  1. Friedman, B.; Cronstein, B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019, 86(3), 301-307.
  2. Sasso, S.P.; Gilli, R.M.; Sari, J.C.; Rimet, O.S.; Briand, C.M. Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochim Biophys Acta. 1994, 20, 1207(1), 74-9.
  3. Pittman, S.M.; Strickland, D.; Ireland, C.M. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994, 215 (2), 263-72.