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Thermo Scientific Chemicals
Progesterone, 98%, Thermo Scientific Chemicals
Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.
化学物質識別子
CAS57-83-0
IUPAC Name(1S,3aS,3bS,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Molecular FormulaC21H30O2
InChI KeyRJKFOVLPORLFTN-LEKSSAKUSA-N
SMILESCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
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仕様
スペックシート
スペックシートAppearance (Color)White to off-white
Melting point126°C to 131°C
Specific optical rotation+186° to +194° (20°C, 589 nm) (c=1, ethanol)
Specific optical rotationon dried substance
Infrared spectrumConforms
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation
• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility
Applications
• Progesterone signaling is relevant to the study of breast cancer
Literature References
Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.
Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.
RUO – Research Use Only
Literature References
Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.
Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.