Puromycin dihydrochloride hydrate, 99%

Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis.

製品番号（カタログ番号）	数量	パッケージ
227420100	10 mg	Glass bottle

製品番号（カタログ番号） 227420100

価格（JPY）

10 mg

パッケージ:

Glass bottle

一括またはカスタム形式をリクエストする

化学物質識別子

CAS58-58-2

IUPAC Name(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride

Molecular FormulaC22H31Cl2N7O5

InChI KeyMKSVFGKWZLUTTO-MLYJQVMKNA-N

SMILESCl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

さらに表示

Appearance (Form)Powder

HPLC>=98.5 %

Infrared spectrumConforms

Appearance (Color)White to light beige

Water=<12 %

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis

Applications

• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.

RUO – Research Use Only

General References:

Rosson, R. A.; Tebo, B. M.; Nealson, K. H. Use of poisons in determination of microbial manganese binding rates in seawater. Appl. Environ. Microbiol. 1984, 47, (7), 740-745.
Nair, V.; Emanuel, D. J.. Synthetic design, stereochemistry, and enzymic activity of a reversed aminoacyl nucleoside: an analog of puromycin. J. Am. Chem. Soc. 1977, 99, (5), 1571-1576.