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Thermo Scientific Chemicals
Puromycin dihydrochloride hydrate, 99%
Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis.
化学物質識別子
CAS58-58-2
IUPAC Name(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
Molecular FormulaC22H31Cl2N7O5
InChI KeyMKSVFGKWZLUTTO-MLYJQVMKNA-N
SMILESCl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1
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仕様
スペックシート
スペックシートAppearance (Form)Powder
HPLC>=98.5 %
Infrared spectrumConforms
Appearance (Color)White to light beige
Water=<12 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis
Applications
• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.
RUO – Research Use Only
Literature References
Rosson, R. A.; Tebo, B. M.; Nealson, K. H. Use of poisons in determination of microbial manganese binding rates in seawater. Appl. Environ. Microbiol. 1984, 47, (7), 740-745.
Nair, V.; Emanuel, D. J.. Synthetic design, stereochemistry, and enzymic activity of a reversed aminoacyl nucleoside: an analog of puromycin. J. Am. Chem. Soc. 1977, 99, (5), 1571-1576.