Search
元素の検索
構造の検索
Thermo Scientific Chemicals
Cytochalasin B
Cytochalasin B, CAS# 14930-96-2, also known as phomin, is an organic heterotricyclic compound that is a cell-permeable mycotoxin with potent activity to inhibit cytoplasmic division. | CAS: 14930-96-2 | C29H37NO5 | 479.62 g/mol
化学物質識別子
CAS14930-96-2
スペックシートThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Cytochalasin B is a cell-permeable fungal toxin / mycotoxin considered to be an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments
Applications
• Cytochalasin B can inhibit platelet aggregation and actin polymerization
• Cytochalasin B is commonly used in studies on cytokinesis due to its ability to act as an inhibitor
• It is used for characterizing some of the polymerization properties of actin
• This compound can also induce DNA fragmentation, inhibit cell division, and inhibit glucose transport, among other molecular processes
• It could be used as a probe for the two hexose-transport systems in rat L6 myoblasts
• Cytochalasin B is commonly used in studies of glucose transporters (GLUT)
• It can be used in in vitro micronucleus assay protocols
RUO – Research Use Only
General References:
- Brzozowska, K.; Johannes, C.; Obe, G.; Hentschel, R.; Morand, J.; Moss, R.; Wittig, A.; Sauerwein, W.; Liniecki, J.; Szumiel, I.; Wojcik, A. Effect of temperature during irradiation on the level of micronuclei in human peripheral blood lymphocytes exposed to X-rays and neutrons. Int J Radiat Biol. 2009, 85, (10), 891-899.
- MacLean-Fletcher, S.; Pollard, T. D. Mechanism of action of cytochalasin B on actin. Cell. 1998, 20, (2), 329-341.
- Fenech, M.; Morley, A. A. Measurement of micronuclei in lymphocytes. Mutation Research/Environmental Mutagenesis and Related Subjects. 1985, 147, (1-2), 29-36.