Bilirubin, 98+%

Name: Bilirubin, 98+%
SKU: 230220010

Bilirubin, CAS # 635-65-4, is a tetrapyrroliccompound found in bile that is a product of heme catabolism. | CAS: 635-65-4 | C33H36N4O6 | 584.67 g/mol

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数量:

1 g

5 g

パッケージ:

Glass bottle

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製品番号（カタログ番号） 230220010

価格（JPY）

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数量:

1 g

パッケージ:

Glass bottle

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化学物質識別子

CAS635-65-4

IUPAC Name3-(2-{[3-(2-carboxyethyl)-5-{[(2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-2-yl]methyl}-5-{[(2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-3-yl)propanoic acid

Molecular FormulaC33H36N4O6

InChI KeyBPYKTIZUTYGOLE-IFADSCNNSA-N

SMILESCC1=C(C=C)\C(NC1=O)=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\C=C2/NC(=O)C(C=C)=C2C)N1

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仕様

スペックシート

Appearance (Form)Powder

Water=<1 % (K.F.)

Appearance (Color)Orange to red to brown

Infrared spectrumConforms

UV Lambda max450 to 454 nm (in CHCl3)

さらに表示

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Bilirubin is a degradation product of heme following the activity of heme oxidase. Bilirubin is produced in the reticuloendothelial system and conjugated in the liver. It appears as an orange-yellow pigment that is secreted in the bile
High levels of unconjugated bilirubin can result in jaundice, a condition of the yellowing of skin and eyes. This can be toxic and may be a sign of severe liver disease
Bilirubin has been seen to have functions including cell signaling, metabolism modulation, and immune regulation
It has protective antioxidant activity at moderate levels

Application

Bilirubin is widely used in studies of liver function and disease, such as hepatitis or cirrhosis
As an antioxidant, bilirubin has been studied in protection against H2O2-mediated cell death
It can be used as a scavenger of reactive oxygen species (ROS) or as an inhibitor of NADPH oxidase

RUO – Research Use Only

General References:

Hinds TD Jr, Stec DE. Bilirubin, a Cardiometabolic Signaling Molecule. Hypertension. 2018 Oct;72(4):788-795. doi: 10.1161/HYPERTENSIONAHA.118.11130. Erratum in: Hypertension. 2018 Dec;72(6):e95. PMID: 30354722; PMCID: PMC6205727.
Vítek L, Tiribelli C. Bilirubin: The yellow hormone? J Hepatol. 2021 Dec;75(6):1485-1490. doi: 10.1016/j.jhep.2021.06.010. Epub 2021 Jun 18. PMID: 34153399.