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Thermo Scientific Chemicals
Hydroxychloroquine sulfate, 98%
Hydroxychloroquine sulfate, CAS # 747-36-4, is a chemical compound with antiparasitic, antiviral, and anti-rheumatic activities. | CAS: 747-36-4 | C18H26ClN3O·H2SO4 | 433.96 g/mol
化学物質識別子
CAS747-36-4
IUPAC Name2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; sulfuric acid
Molecular FormulaC18H28ClN3O5S
InChI KeyJCBIVZZPXRZKTI-UHFFFAOYNA-N
SMILESOS(O)(=O)=O.CCN(CCO)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
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仕様
スペックシート
スペックシートAppearance (Form)Crystalline powder
Loss on drying=<2 % (105°C, 2 h)
Chloride (Cl)=<350 ppm
Appearance (Color)White to off-white
UV spectrophotometry>=97.5 % (on dried basis)
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Hydroxychloroquine sulfate shows antimalarial activity against malaria parasites mainly in the intra-erythrocytic phase of its life cycle. It acts by inhibiting the heme polymerase inside the food vacuole of the parasites
- It shows an inhibitory activity in autophagy preventing the lysosome fusion with the autophagosome
- Some studies demonstrated that hydroxychloroquine sulfate, due to its antiviral activity can restrict HIV infection in vitro
Applications
- Hydroxychloroquine sulfate displays antiviral and anti-rheumatic activities
- In vitro and in vivo experiments have been performed to investigate the role of hydroxychloroquine sulfate in the treatment of SARS-CoV-2 disease
- Hydroxychloroquine sulfate can be used in immunofluorescence assays to evaluate the antiviral mechanisms in dengue virus-2 infection. In this disease, this compound can activate the innate immune response
RUO – Research Use Only