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Thermo Scientific Chemicals
4-Epichlortetracycline hydrochloride, can be used as secondary standard
4-Epichlortetracycline hydrochloride, CAS # 14297-93-9, is a broad-spectrum, bacteriostatic antibiotic of the tetracycline antibiotic family.
化学物質識別子
CAS101342-45-4
IUPAC Name7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboxamide hydrochloride
Molecular FormulaC22H24Cl2N2O8
InChI KeyQYAPHLRPFNSDNH-UHFFFAOYNA-N
SMILESCl.CN(C)C1C2CC3C(=C(O)C4=C(O)C=CC(Cl)=C4C3(C)O)C(=O)C2(O)C(O)=C(C(N)=O)C1=O
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仕様
スペックシート
スペックシートAppearance (Color)Light yellow to yellow-green to orange
Appearance (Form)Powder
Purity>=70 % (as is, calculated)
Infrared spectrumConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• 4-Epichlortetracycline is the hydrochloride salt of 4-Epichlortetracycline, a tetracycline ring structure with a chloride substitution
• 4-Epichlortetracycline hydrochloride (4-Epi-chlortetracycline) is an epimer of chlortetracycline
• 4-Epichlortetracycline suppresses neutrophil activity and dampens the immune response
• Acts as an aminoacyl-tRNA analog to disrupt polypeptide synthesis, reducing bacterial growth Applications
• Can be used for in vitro research on cancer and inflammatory mechanisms
• Intended for use as a selective agent and secondary standard
RUO – Research Use Only
Literature references
Armstrong, A.W.; Hekmatjah, J.; Kircik, L.H. Oral Tetracyclines and Acne: A Systematic Review for Dermatologists. J Drugs Dermatol. 2020, 19(11), s6-s13. Liou, J.M.; Chen, C.C.; Chang, C.M.; Fang, Y.J.; Bair, M.J.; Chen, P.Y.; Chang, C.Y.; Hsu, Y.C.; Chen, M.J.; Chen, C.C.; Lee, J.Y.; Yang, T.H., Luo, J.C.; Chen, C.Y.; Hsu, W.F.; Chen, Y.N.; Wu, J.Y.; Lin, J.T.; Lu, T.P.; Chuang, E.Y.; El-Omar, E.M.; Wu, M.S. Taiwan Gastrointestinal Disease and Helicobacter Consortium. Long-term changes of gut microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication: a multicentre, open-label, randomised trial. Lancet Infect Dis. 2019,(10), 1109-1120.