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Thermo Scientific Chemicals
Prednisolone, 99%, Thermo Scientific Chemicals
Prednisolone, or metacortandralone, CAS # 50-24-8, is a synthetic glucocorticoid.
化学物質識別子
CAS50-24-8
IUPAC Name(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Molecular FormulaC21H28O5
InChI KeyOIGNJSKKLXVSLS-VWUMJDOOSA-N
SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
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仕様
スペックシート
スペックシートHPLC>=98.5 %
Appearance (Color)White to off-white
Specific optical rotation+113° to +119° (20°C, 589 nm) (c=1, ethanol)
Infrared spectrumConforms
Loss on drying=<1 %
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Prednisolone is a derivative of prednisone with an oxo to beta-hydroxy reduction at position 11
• Prednisolone binds cell surface receptors and is transported to the nucleus, where it binds certain nuclear receptors responsible for transcription of proinflammatory cytokines
Applications
• Prednisolone can be used for laboratory research on tumor growth and prevention
• Prednisolone may also be used for developmental and endocrine research, in vivo or in vitro
RUO – Research Use Only
Literature References
Waldrop, M.A.; Karingada, C.; Storey, M.A.; Powers, B.; Lammarino, M.A.; Miller, N.F.; Alfano, L.N.; Noritz, G.; Rossman, I.; Ginsberg, M.; Mosher, K.A., Broomall, E.; Goldstein, J.; Bass, N.; Lowes, L.P.; Tsao, C.Y.; Mendell, J.R.; Connolly, A.M. Gene Therapy for Spinal Muscular Atrophy: Safety and Early Outcomes. Pediatrics. 2020, 146(3), e20200729.
Koumpa, F.S.; Forde, C.T.; Manjaly, J.G. Sudden irreversible hearing loss post COVID-19. BMJ Case Rep. 2020, 13(11), e238419.