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Thermo Scientific Chemicals
Cefoxitin sodium salt, 94%
Cefoxitin sodium salt, CAS # 33564-30-6, is a β-lactam, second-generation cephalosporin compound showing bactericidal activity against Bacteroides, gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis. | CAS: 33564-30-6 | C16H16N3NaO7S2 | 449.428 g/mol
化学物質識別子
CAS33564-30-6
IUPAC Namesodium (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Molecular FormulaC16H16N3NaO7S2
InChI KeyGNWUOVJNSFPWDD-XMZRARIVSA-M
SMILES[Na+].CO[C@]1(NC(=O)CC2=CC=CS2)[C@H]2SCC(COC(N)=O)=C(N2C1=O)C([O-])=O
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仕様
スペックシート
スペックシートAppearance (Color)White to cream
Appearance (Form)Powder
Infrared spectrumConforms
Water=<1 %
Specific optical rotation+206° to +214° (20°C, 589 nm) (c= 1, methanol)
さらに表示
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Cefoxitin sodium salt is resistant to β-lactamase
- It binds and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall thus interfering with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity
Applications
- Cefoxitin sodium salt is the sodium salt form of cefoxitin derived from cephamycin C
- It is a β-lactam, second-generation cephalosporin compound with bactericidal activity against numerous species such as Bacteroides, gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis
- Cefoxitin increases survival in mice infected with S. aureus, S. pyogenes, and K. pneumoniae
RUO – Research Use Only
General References:
- Brogden, R.; Heel, R.; Speight, T.; Avery, G. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979, 17 (1), 1-37.
- Miller, A.K., Celozzi, E., Kong, Y., et al. Cefoxitin, a semisynthetic cephamycin antibiotic: In vivo evaluation. Antimicrob. Agents Chemother. 1974, 5, (1), 33-37.