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Thermo Scientific Chemicals
Cloxacillin sodium salt monohydrate
Cloxacillin sodium salt monohydrate, CAS # 7081-44-9, is a compound that targets gram-positive bacteria and shows antibacterial activity.
化学物質識別子
CAS7081-44-9
IUPAC Namesodium (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
Molecular FormulaC19H19ClN3NaO6S
InChI KeyKCUWTKOTPIUBRI-VICXVTCVSA-M
SMILESO.[Na+].CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)C(=NO1)C1=CC=CC=C1Cl
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White
Appearance (Form)Crystalline powder
Infrared spectrumConforms
HPLC>=94 %
Water3.0 to 5.0 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Cloxacillin sodium salt monohydrate is a chlorinated derivative of oxacillin that shows β-lactamase-resistant antibiotic activity
• This compound inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis, that is mediated by bacterial cell wall autolytic enzymes
Applications
• Cloxacillin sodium salt monohydrate targets gram-positive bacteria, and is effective against staphylococci that produce β-lactamase
• It acts in vitro against both penicillin gram-resistant and gram-sensitive staphylococci, certain streptococci, and pneumococci
• This compound is commonly used in vivo and in vitro studies as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics
RUO – Research Use Only
Literature References
A New Antibacterial Agent: Sodium Cloxacillin Monohydrate (Tegopen). Journal of the American Medical Association. 1966, 195, 569-570.
Harris, P.N.; Ferguson, J.K. Antibiotic therapy for inducible AmpC β-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012, 40, (4), 297-305.