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Thermo Scientific Chemicals
Finasteride, 98%
Finasteride, CAS # 98319-26-7, is a 5α-reductase inhibitor that blocks conversion of testosterone and inhibits neurosteroid production.
| 製品番号（カタログ番号） | 数量 |
|---|---|
| 458000050 | 5g |
化学物質識別子
CAS98319-26-7
IUPAC Name(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H,11H,11aH-indeno[5,4-f]quinoline-7-carboxamide
Molecular FormulaC23H36N2O2
InChI KeyDBEPLOCGEIEOCV-WSBQPABSSA-N
SMILESCC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White to beige
Infrared spectrumConforms
HPLC>=97.5 %
Water=<0.5 %
Appearance (Form)Crystalline powder
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Finasteride is an inhibitor of the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT)
• Finasteride also has been explored in neuroscience, as 5α-reductase enzymes are present in the central nervous system
• Finasteride has been seen to cross the blood-brain barrier and block production of neurosteroids
Applications
• Finasteride is mainly used in studies of prostate hyperplasia and tumors in mice, and can be studied in vitro or in vivo for its effects on hyperplasia, proliferation, and antioxidant activity
• Its activity has also been explored in brain, liver and testis tissues
• In vivo injection of finasteride has been shown to decrease neurogenesis and influence neuronal plasticity in mice
RUO – Research Use Only
Literature references
Kim, H.J.; Kim, T.J.; Kim, Y.G.; Seong, C.; Cho, J.H.; Kim, W.; Lee, K.H.; Kim, D.Y. Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Pharmaceutics. 2021, 13(9), 1410.
Chhipa, R.R.; Halim, D.; Cheng, J.; Zhang, H.Y.; Mohler, J.L.; Ip, C.; Wu, Y. The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific. Prostate. 2013, 73(14), 1483-94.
Römer, B.; Pfeiffer, N.; Lewicka, S.; Ben-Abdallah, N.; Vogt, M.A.; Deuschle, M.; Vollmayr, B.; Gass, P. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Pharmacopsychiatry. 20100, 43(5), 174-8.