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Thermo Scientific Chemicals
Gabapentin, 98%
Gabapentin, CAS # 60142-96-3, is a synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant and analgesic activities. | CAS: 60142-96-3 | C9H17NO2 | 171.24 g/mol
化学物質識別子
CAS60142-96-3
IUPAC Name2-[1-(aminomethyl)cyclohexyl]acetic acid
Molecular FormulaC9H17NO2
InChI KeyUGJMXCAKCUNAIE-UHFFFAOYSA-N
SMILESNCC1(CC(O)=O)CCCCC1
さらに表示
仕様
スペックシート
スペックシートAppearance (Form)Powder
Appearance (Color)White to almost white
Infrared spectrumConforms
Melting point162°C to 168°C
Titration with HClO4>=97.5 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Gabapentin is a water-soluble GABA analog with anticonvulsant and analgesic activities
- The exact mechanism of action is unknown but it has been described that this compound inhibits excitatory neuron activity by interacting with voltage-gated calcium channels in cortical neurons
Application
- Gabapentin has been used as the α2δ-ligand to examine whether the allyl isothiocyanate (AITC) sensitized thermal aversion assay might be useful as a screening method for the identification of presumptive analgesics
RUO – Research Use Only
General References:
- Curtright, A.; Rosser, M.; Goh, S.; Keown, B.; Wagner, E.; Sharifi, J.; Raible, D.W.; Dhaka, A. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One. 2015, 14, 10, (1), e0116766.
- Yasaei, R.; Katta, S.; Saadabadi, A. Gabapentin. [Updated 2021 Dec 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.