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Thermo Scientific Chemicals
3-Butyn-1-ol, 98%
CAS: 927-74-2 | C4H6O | 70.091 g/mol
化学物質識別子
CAS927-74-2
IUPAC Namebut-3-yn-1-ol
Molecular FormulaC4H6O
InChI KeyOTJZCIYGRUNXTP-UHFFFAOYSA-N
SMILESOCCC#C
さらに表示
仕様
スペックシート
スペックシートRefractive Index1.4385-1.4425 @ 20?C
Appearance (Color)Clear colorless to yellow
FormLiquid
Assay (GC)≥97.5%
3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.
Solubility
Miscible with alcohols and organic solvents. Immiscible with aliphatic hydrocarbon solvents.
Notes
Incompatible with strong oxidizing agents, acids, acid anhydrides and copper.
3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.
Solubility
Miscible with alcohols and organic solvents. Immiscible with aliphatic hydrocarbon solvents.
Notes
Incompatible with strong oxidizing agents, acids, acid anhydrides and copper.
RUO – Research Use Only
General References:
- For examples of Sonogashira coupling with aryl iodides in the presence of trans-Dichlorobis(triphenyl phosphine) palladium(II) , 10491, CuI and Et3N in acetonitrile, see: J. Med. Chem., 38, 1837 (1995).
- The triflate ester cyclizes on prolonged reaction with Na trifluoroacetate in TFA to give cyclobutanone: Org. Synth. Coll., 6, 324 (1988).
- Yin, S.; Dong, L.; Xia, Y.; Dong, B.; He, X.; Chen, D.; Qiu, H.; Song, B. Controlled self-assembly of a pyrene-based bolaamphiphile by acetate ions: from nanodisks to nanofibers by fluorescence enhancement. Soft matter 2015, 11 (22), 4424-4429.
- Tan, W.; Li, Q.; Li, W.; Dong, F.; Guo, Z. Synthesis and antioxidant property of novel 1, 2, 3-triazole-linked starch derivatives via ‘click chemistry’. Int. J. Biol. Macromol. 2016, 82, 404-410.