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Thermo Scientific Chemicals
2-Fluoropyridine, 99%
CAS: 372-48-5 | C5H4FN | 97.092 g/mol
化学物質識別子
CAS372-48-5
IUPAC Name2-fluoropyridine
Molecular FormulaC5H4FN
InChI KeyMTAODLNXWYIKSO-UHFFFAOYSA-N
SMILESFC1=CC=CC=N1
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仕様
スペックシート
スペックシートRefractive Index1.4655-1.4685 @ 20?C
Appearance (Color)Clear colorless to pale yellow
Assay (GC)≥98.5%
Identification (FTIR)Conforms
FormLiquid
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
Solubility
Soluble in water.
Notes
Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizing agents.
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
Solubility
Soluble in water.
Notes
Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizing agents.
RUO – Research Use Only
General References:
- Lubov Pasumansky; Armando R. Hernández; Soya Gamsey; Christian T. Goralskib; Bakthan Singaram. Synthesis of aminopyridines from 2-fluoropyridine and lithium amides. Tetrahedron Letters.2004, 45 413-417.
- The possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine makes 2-fluoropyridine a useful precursor of a wide range of 2,3-disubstituted pyridines. See, e.g.: J. Org. Chem., 53, 2740 (1988):