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Thermo Scientific Chemicals
6-Mercaptopurine monohydrate, 98%
CAS: 6112-76-1 | C5H6N4OS | 170.19 g/mol
化学物質識別子
CAS6112-76-1
IUPAC Name6,7-dihydro-3H-purine-6-thione hydrate
Molecular FormulaC5H6N4OS
InChI KeyWFFQYWAAEWLHJC-UHFFFAOYSA-N
SMILESO.S=C1N=CNC2=C1NC=N2
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)Yellow
FormPowder
Assay (HPLC)≥97.5%
Water Content (Karl Fischer Titration)9-13%
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
Solubility
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
Solubility
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.
- John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.