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Thermo Scientific Chemicals
3,4-(Methylenedioxy)aniline, 98+%
CAS: 14268-66-7 | C7H7NO2 | 137.138 g/mol
化学物質識別子
CAS14268-66-7
IUPAC Name2H-1,3-benzodioxol-5-amine
Molecular FormulaC7H7NO2
InChI KeyXGNXYCFREOZBOL-UHFFFAOYSA-N
SMILESNC1=CC=C2OCOC2=C1
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)Dark brown to brown to black
Assay (GC)≥98.0%
Identification (FTIR)Conforms
Melting Point (clear melt)39.0-47.0?C
FormCrystals or powder or crystalline powder or chunks or fused solid or liquid as melt
3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.
Solubility
Slightly soluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to strong acids, acid chlorides, acid anhydrides. Air & Light Sensitive. Stable under recommended storage conditions.
3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.
Solubility
Slightly soluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to strong acids, acid chlorides, acid anhydrides. Air & Light Sensitive. Stable under recommended storage conditions.
RUO – Research Use Only
General References:
- SJ Tu.; XD Cao.; WJ Hao.; XH Zhang .; S Yan. An efficient and chemoselective synthesis of benzo [e][1, 4] thiazepin-2 (1 H, 3 H, 5 H)-ones via a microwave-assisted multi-component reaction in water. Organic & Biomolecular Chemistry. 20097, (3) , 557-563.
- MJ Luzzio.; JM Besterman.; DL Emerson. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J. Med. Chem. 199538, (3) , 395-401.