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Thermo Scientific Chemicals
1-Chloro-3-iodopropane, 98%, stab. with copper
CAS: 6940-76-7 | C3H6ClI | 204.435 g/mol
化学物質識別子
CAS6940-76-7
IUPAC Name1-chloro-3-iodopropane
Molecular FormulaC3H6ClI
InChI KeySFOYQZYQTQDRIY-UHFFFAOYSA-N
SMILESClCCCI
さらに表示
仕様
スペックシート
スペックシートFormLiquid
Appearance (Color)Clear, colourless to yellow to orange or pale brown
Assay (GC)≥97.5%
StabilizerCopper powder
Refractive Index1.5440-1.5490 @ 20?C
1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.
Solubility
Difficult to mix.
Notes
Light Sensitive. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.
Solubility
Difficult to mix.
Notes
Light Sensitive. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Jen-Yen Cheng.; Yen-Ho Chu. 1-Butyl-2,3-trimethyleneimidazolium bis(trifluoromethylsulfonyl)imide ([b-3C-im][NTf2]): a new, stable ionic liquid. Tetrahedron Letters. 2006, 47, (10), 1575-1579.
- T. B. Scoggins.; J. M. White. The Thermal Chemistry of 1-Chloro-3-Iodopropane (ClC3H6I) Adsorbed on Pt(111). J. Phys. Chem. B. 1999, 103, (44), 9663-9672.
- Bifunctional alkylating agent in which the two halogens may be displaced successively with different nucleophiles. For use in the alkylation of diphenyl sulfide and cyclization to the cyclopropyl diphenyl sulfonium salt, see: Org. Synth. Coll., 6, 364 (1988).