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Thermo Scientific Chemicals
Ethyl oxalyl chloride, 98%
CAS: 4755-77-5 | C4H5ClO3 | 136.531 g/mol
化学物質識別子
CAS4755-77-5
IUPAC Nameethyl oxalochloridate
Molecular FormulaC4H5ClO3
InChI KeyOWZFULPEVHKEKS-UHFFFAOYSA-N
SMILESCCOC(=O)C(Cl)=O
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仕様
スペックシート
スペックシートRefractive Index1.4150-1.4190 @ 20°C
FormLiquid
Assay (GC)≥97.5%
Appearance (Color)Clear colorless to pale yellow
Identification (FTIR)Conforms
Ethyl oxalyl chloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. It acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Ethyl oxalyl chloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. It acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.
Solubility
Slightly miscible with water.
Notes
Moisture sensitive. Incompatible with bases, oxidizing agents and alcohols.
Ethyl oxalyl chloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. It acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.
Solubility
Slightly miscible with water.
Notes
Moisture sensitive. Incompatible with bases, oxidizing agents and alcohols.
RUO – Research Use Only
General References:
- Reaction with imidazole, followed by a Grignard reagent, provides a route to ɑ-keto esters, generally in good yield: J. Org. Chem., 46, 211 (1981).
- In the presence of pyridine, electron-rich alkenes give 2-oxo-3-alkenoic esters: Synthesis, 137 (1986):
- Zang, T. N.; Zhao, R. R.; Yang, X. Z.; Gao, Y.; Wang, G. K.; Zhou, Y.; Zhang, J. F. A near-infrared chemodosimeter with Pi-selective colorimetric and fluorescent sensing and its application in vivo imaging. RSC Adv. 2015, 5 (88), 71756-71759.
- Monascal, Y.; Maldonado, A.; Mora, J. R.; Córdova, T.; & Chuchani, G. Homogeneous and unimolecular gas-phase thermal decomposition kinetics of methyl benzoylformate: experimental and theoretical study. J. Phys. Org. Chem. 2015, 28 (1), 40-46.