A-23187 Free Acid (Calcimycin)
A-23187 Free Acid (Calcimycin)
Citations & References (397)
Invitrogen™

A-23187 Free Acid (Calcimycin)

通常、Ca2+イオノフォアA-23187は蛍光Ca2+インジケータのIn-situ校正に使用され、細胞内および細胞外のCa2+濃度を平衡化し、Mn2+を細胞内に侵入させて細胞内色素蛍光を消光します。A-23197の内在蛍光はfura-2、indo-1、quin-2などのUV刺激性カルシウムインジケータとの併用には高すぎますが、fluo-4、fluo-3、Calcium詳細を見る
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製品番号（カタログ番号）数量
A149310 mg
製品番号（カタログ番号） A1493
価格（JPY）
29,500
온라인 행사
Ends: 26-Dec-2025
49,300
割引額 19,800 (40%)
Each
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数量:
10 mg
通常、Ca2+イオノフォアA-23187は蛍光Ca2+インジケータのIn-situ校正に使用され、細胞内および細胞外のCa2+濃度を平衡化し、Mn2+を細胞内に侵入させて細胞内色素蛍光を消光します。A-23197の内在蛍光はfura-2、indo-1、quin-2などのUV刺激性カルシウムインジケータとの併用には高すぎますが、fluo-4、fluo-3、Calcium Green、rhod-2などの可視光刺激性インジケータとの併用には適しています。A-23187は、細胞外および細胞内のMg2+濃度の平衡化にも使用できるため、Mg2+インジケータの校正にも役立ちます。

カルシウム、カリウム、pH、膜電位インジケータなど、イオンインジケータの詳細を見る›

研究用にのみ使用できます。診断用には使用いただけません。
仕様
検出法蛍光
使用対象 (装置)蛍光顕微鏡, フローサイトメーター, フローメーター, 蛍光イメージャー
インジケーターカルシウムインジケーター
分子式C29H37N3O6
数量10 mg
推奨保存方法冷凍庫内で保管し（-5～-30℃）、遮光してください。
出荷条件室温
物理的フォームSolid
製品タイプCalcimycin
Unit SizeEach

引用および参考文献 (397)

引用および参考文献
Abstract
Flow cytometric measurement of the production of reactive oxygen intermediate in activated rat mast cells.
Authors:Tsinkalovsky OR, Laerum OD
Journal:APMIS
PubMed ID:7520710
The production of reactive oxygen intermediates (ROI) in compound 48/80- or calcium ionophore A 23187- activated pleural or peritoneal mast cells was monitored using flow cytometry and the fluorescence indicator dihydrorhodamine 123 (a derivate of rhodamine 123). Mast cell degranulation and ROI production were estimated by flow cytometric fluorescence and ... More
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
Authors:Diatchuk V, Lotan O, Koshkin V, Wikstroem P, Pick E
Journal:J Biol Chem
PubMed ID:9148950
The elicitation of an oxidative burst in phagocytes rests on the assembly of a multicomponental complex (NADPH oxidase) consisting of a membrane-associated flavocytochrome (cytochrome b559), representing the redox element responsible for the NADPH-dependent reduction of oxygen to superoxide (O-2), two cytosolic components (p47(phox), p67(phox)), and the small GTPase Rac (1 ... More
Exocytotic insertion of calcium channels constrains compensatory endocytosis to sites of exocytosis.
Authors:Smith RM, Baibakov B, Ikebuchi Y, White BH, Lambert NA, Kaczmarek LK, Vogel SS
Journal:J Cell Biol
PubMed ID:10684256
'Proteins inserted into the cell surface by exocytosis are thought to be retrieved by compensatory endocytosis, suggesting that retrieval requires granule proteins. In sea urchin eggs, calcium influx through P-type calcium channels is required for retrieval, and the large size of sea urchin secretory granules permits the direct observation of ... More
Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice.
Authors:Huang C, Mattjus P, Ma WY, Rincon M, Chen NY, Brown RE, Dong Z
Journal:J Biol Chem
PubMed ID:10734048
'Mammalian cells respond to UV radiation by signaling cascades leading to activation of transcription factors, such as activated protein 1, NFkappaB, and p53, a process known as the "UV response." Nuclear factor of activated T cells (NFAT) was first identified as an inducible nuclear factor in immune response and subsequently ... More
Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
Authors:Peters D, Tsuchida M, Manthei ER, Alam T, Cho CS, Knechtle SJ, Hamawy MM
Journal:Blood
PubMed ID:10779414
'The activation of blood cells, including T cells, triggers intracellular signals that control the expression of critical molecules, including cytokines and cytokine receptors. We show that T-cell receptor (TCR) ligation increases the cellular level of the protein linker for activation of T cells (LAT), a molecule critical for T-cell development ... More
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