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Thermo Scientific Chemicals
cis-Aconitic anhydride, 98%
CAS: 6318-55-4 | C6H4O5 | 156.093 g/mol
化学物質識別子
CAS6318-55-4
IUPAC Name2-(2,5-dioxo-2,5-dihydrofuran-3-yl)acetic acid
Molecular FormulaC6H4O5
InChI KeyGVJRTUUUJYMTNQ-UHFFFAOYSA-N
SMILESOC(=O)CC1=CC(=O)OC1=O
さらに表示
仕様
スペックシート
スペックシートFormPowder or crystalline powder
Appearance (Color)White to cream to pale brown
Assay (Aqueous acid-base Titration)≥97.5 to ≤102.5%
Infrared spectrumConforms
Melting Point (clear melt)71-79°C
さらに表示
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Notes
Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Notes
Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.
RUO – Research Use Only
General References:
- Sun, D.; Ding, J.; Xiao, C.; Chen, J.; Zhuang, X.; Chen, X. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent. Adv. Healthcare Mater. 2015, 4 (6), 844-855.
- Chen, J.; Ding, J.; Zhang, Y.; Xiao, C.; Zhuang, X.; Chen, X. Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery. Polym. Chem. 2015, 6 (3), 397-405.