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2-Fluoro-4-methylaniline, 99%, Thermo Scientific Chemicals
化学物質識別子
CAS452-80-2
IUPAC Name2-fluoro-4-methylaniline
Molecular FormulaC7H8FN
InChI KeyZQEXBVHABAJPHJ-UHFFFAOYSA-N
SMILESCC1=CC=C(N)C(F)=C1
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)Clear colorless or yellow to orange or pale red to dark red to pale brown
FormLiquid
Assay (GC)≥98.5%
Refractive Index1.5310-1.5340 @ 20°C
2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
Solubility
Not miscible in water.
Notes
Store in a cool, dry, conditions in well sealed container. Store away from oxidizing agents.
2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
Solubility
Not miscible in water.
Notes
Store in a cool, dry, conditions in well sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Sharon T Marino; Danuta Stachurska-Buczek; Daniel A Huggins; Beata M Krywult; Craig S Sheehan; Thao Nguyen; Neil Choi, Jack G Parsons; Peter G Griffiths; Ian W James; Andrew M Bray; Jonathan M White; Rustum S Boyce. Synthesis of chiral building blocks for use in drug discovery. Molecules. 2004, 9 (6), 405-426.
- S Boeren; B Tyrakowska; J Vervoort; E De Hoffman; K Teunis; A van Veldhuizen; I M Rietjens. Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica. 1992, 22 (12), 1403-1423.