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Thermo Scientific Chemicals
Rose Bengal
CAS: 632-69-9 | C20H4Cl4I4Na2O5 | 1019.644 g/mol
化学物質識別子
CAS632-69-9
IUPAC Namedisodium 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-bis(olate)
Molecular FormulaC20H2Cl4I4Na2O5
InChI KeyKCQREHTWEUECQT-UHFFFAOYSA-L
SMILES[Na+].[Na+].[O-]C1=C(I)C=C2C(OC3=C(I)C([O-])=C(I)C=C3C22OC(=O)C3=C(Cl)C(Cl)=C(Cl)C(Cl)=C23)=C1I
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仕様
スペックシート
スペックシートSolution Test0.1 wt.% in water (+ 1ml 1% Na₂CO₃): Clear
lambda-max (UV-Vis)540-550nm (in water)
Specific Absorbance (E 1%/1cm)(at |l max) : ≥600
Appearance (Color)Red to dark red to brown
FormPowder
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Rose Bengal is a stain used in the eye drops to identify the eye damage. It finds application in the preparation of foraminifera for microscopic analysis, photosensitizing reactions and as a dye. In synthetic chemistry, it is utilized to convert triplet oxygen to singlet oxygen, which is used in [2+2] cycloadditions with alkenes. Its derivatives have important medical functions and used for the treatment of cancer. It acts as an alternative to phloxine B in Kreyberg's stain for keratin and mucus. As a fluorescent probe, it is used for the determination of NAD binding sites of alcohol dehydrogenase.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in water.
Notes
Incompatible with strong oxidizing agents.
Soluble in water.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Yuan, K.; Wang, J.; Zhai, H.; Chen, Z.; Huang, L.; Su, Z. Sensitive determination of rose bengal in brown sugar by a molecularly imprinted solid-phase extraction monolithic capillary column coupled with capillary electrophoresis. Anal. Methods 2015, 7 (19), 8297-8303.
- Lee, J. S.; Lee, B. I.; Park, C. B. Photo-induced inhibition of Alzheimer's beta-amyloid aggregation in vitro by rose bengal. Biomater. 2015, 38, 43-49.