BODIPY™ FL ATP-γ-S, Thioester (Adenosine 5'-O-(3-Thiotriphosphate), BODIPY™ FL Thioester, Sodium Salt)

BODIPY™ FL ATP-γ-S, Thioester (Adenosine 5'-<i>O</i>-(3-Thiotriphosphate), BODIPY™ FL Thioester, Sodium Salt)

Citations & References (4)

Invitrogen™

BODIPY™ FL ATP-γ-S, Thioester (Adenosine 5'-O-(3-Thiotriphosphate), BODIPY™ FL Thioester, Sodium Salt)

BODIPY™ FL ATP-γ-SはATP結合タンパク質に結合します。この蛍光ヌクレオチドを作成するために、BODIPY FLのフルオロフォアがATP-γ-Sのγ-チオールを介して結合されています。BODIPY FL ATP-γ- Sのチオエーテルは詳細を見る

製品番号（カタログ番号）	数量
A22184	50 µL

製品番号（カタログ番号） A22184

価格（JPY）

140,400

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50 µL

BODIPY™ FL ATP-γ-SはATP結合タンパク質に結合します。この蛍光ヌクレオチドを作成するために、BODIPY FLのフルオロフォアがATP-γ-Sのγ-チオールを介して結合されています。BODIPY FL ATP-γ- Sのチオエーテルは、結合研究で利用できる可能性に加え、ヌクレオチド結合タンパク質のヒスチジンスーパートライアドファミリーのメンバーであるFhitにとって重要な新しい基質です。

研究用にのみ使用できます。診断用には使用いただけません。

標識または色素BODIPY™ FL

製品タイプFL ATP-γ-Sチオエステル

数量50 µL

出荷条件湿氷

濃度5 mM

製品ラインBODIPY

Unit SizeEach

組成および保存条件

フリーザー（-5℃～-30℃）に保存し、遮光してください。

引用および参考文献 (4)

引用および参考文献

Abstract

Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates.

Authors:Draganescu A, Hodawadekar SC, Gee KR, Brenner C

Journal:J Biol Chem

PubMed ID:10671479

'Fhit, a member of the histidine triad superfamily of nucleotide-binding proteins, binds and cleaves diadenosine polyphosphates and functions as a tumor suppressor in human epithelial cancers. Function of Fhit in tumor suppression does not require diadenosine polyphosphate cleavage but correlates with the ability to form substrate complexes. As diadenosine polyphosphates ... More

Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs.

Authors:Korlach J, Baird DW, Heikal AA, Gee KR, Hoffman GR, Webb WW

Journal:Proc Natl Acad Sci U S A

PubMed ID:14973186

Regulated guanosine nucleotide exchange and hydrolysis constitute the fundamental activities of low molecular weight GTPases. We show that three guanosine 5'-triphosphate analogs with BODIPY fluorophores coupled via the gamma phosphate bind to the GTPases Cdc42, Rac1, RhoA, and Ras and displace guanosine 5'-diphosphate with high intrinsic exchange rates in the ... More

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.

Authors:Pace HC, Hodawadekar SC, Draganescu A, Huang J, Bieganowski P, Pekarsky Y, Croce CM, Brenner C

Journal:Curr Biol

PubMed ID:10959838

BACKGROUND: The nucleotide-binding protein Fhit, among the earliest and most frequently inactivated proteins in lung cancer, suppresses tumor formation by inducing apoptosis. In invertebrates, Fhit is encoded as a fusion protein with Nit, a member of the nitrilase superfamily. In mice, the Nit1 and Fhit genes have nearly identical expression ... More

Exploration of the Effects of γ-Phosphate-Modified ATP Analogues on Histidine Kinase Autophosphorylation.

Authors:

Journal:Biochemistry

PubMed ID:29944360