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Thermo Scientific Chemicals
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, 97%
CAS: 77377-52-7 | C9H18F3NOSi | 241.329 g/mol
化学物質識別子
CAS77377-52-7
IUPAC NameN-(butyldimethylsilyl)-2,2,2-trifluoro-N-methylacetamide
Molecular FormulaC9H18F3NOSi
InChI KeyNEJIKZHUEMMAEF-UHFFFAOYSA-N
SMILESCCCC[Si](C)(C)N(C)C(=O)C(F)(F)F
さらに表示
仕様
スペックシート
スペックシートRefractive Index1.3995-1.4045 @ 20?C
Appearance (Color)Clear colorless to pale yellow
Identification (FTIR)Conforms
FormLiquid
Assay (GC)≥96.0%
It finds its application in the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from hydrolysis of nitrogen mustards and a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatography-mass spectrometry (GC-MS) analysis and selective O-silylation of N,O-diacylhydroxylamines and GLC derivatization.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It finds its application in the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from hydrolysis of nitrogen mustards and a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatography-mass spectrometry (GC-MS) analysis and selective O-silylation of N,O-diacylhydroxylamines and GLC derivatization.
Solubility
Soluble in water (reacts).
Notes
Moisture sensitive. Store away from water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store away from electrostatic charges. Keep ignition sources away.
It finds its application in the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from hydrolysis of nitrogen mustards and a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatography-mass spectrometry (GC-MS) analysis and selective O-silylation of N,O-diacylhydroxylamines and GLC derivatization.
Solubility
Soluble in water (reacts).
Notes
Moisture sensitive. Store away from water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store away from electrostatic charges. Keep ignition sources away.
RUO – Research Use Only
General References:
- Ali Shareef, et al. Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17α-ethinylestradiol by gas chromatography-mass spectrometry.J. Chromatogr. A.,2006,1108(1), 121-128.
- A. Royer, et al. Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide.J. Chromatogr. A.,2006,1108(1), 129-135.
- Reactive silylating agent effective in acetonitrile for introduction of the TBDMS group with alcohols, thiols, amines, amides, carboxylic acids, as well as conversion of enolizable carbonyl groups to silyl enol ethers: J. Org. Chem., 47, 3336 (1982). See Appendix 4.