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6(5H)-Phenanthridinone, 96%, Thermo Scientific Chemicals
製品番号（カタログ番号）： B25187.06
5 g, Each
化学物質識別子
CAS
1015-89-0
IUPAC Name
5,6-dihydrophenanthridin-6-one
Molecular Formula
C13H9NO
InChI Key
RZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILES
O=C1NC2=CC=CC=C2C2=CC=CC=C12
仕様
スペックシートAppearance (Color)
Cream to pale brown
Form
Powder
Assay (HPLC)
≥95.0%
Melting Point (clear melt)
288.0-298.0?C
概要
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.
Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.
Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
RUO – Research Use Only
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