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Thermo Scientific Chemicals
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%
CAS: 128625-52-5 | C18H28F6N6OP2 | 520.401 g/mol
化学物質識別子
CAS128625-52-5
IUPAC Name(1H-1,2,3-benzotriazol-1-yloxy)tris(pyrrolidin-1-yl)phosphanium
Molecular FormulaC18H28N6OP
InChI KeyWGNZRLMOMHJUSP-UHFFFAOYSA-N
SMILESC1CCN(C1)[P+](ON1N=NC2=CC=CC=C12)(N1CCCC1)N1CCCC1
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White to pale cream
FormCrystals or powder or crystalline powder
Assay (HPLC)≥97.5%
Identification (FTIR)Conforms
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
Solubility
Soluble in chloroform.
Notes
Store in a cool place. Incompatible with oxidizing agents and water.
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
Solubility
Soluble in chloroform.
Notes
Store in a cool place. Incompatible with oxidizing agents and water.
RUO – Research Use Only
General References:
- Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yl oxytris(dimethyl amino) phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).
- Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L. R.; Low, J. N. Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry. Chem. Commun. 2015, 51 (14), 2832-2835.
- Raibaut, L.; Drobecq, H.; Melnyk, O. Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds. Org. Lett. 2015, 17 (14), 3636-3639.