Brefeldin A (from Penicillium brefeldianum)

Brefeldin A (from <i>Penicillium brefeldianum</i>)

Citations & References (173)

Invitrogen™

Brefeldin A (from Penicillium brefeldianum)

真菌代謝物ブレフェルジンA（BFA）は細胞内に複数の標的を有し、新たに合成されたタンパク質の核外輸送に関与する小胞形成やキナーゼ分布などの細胞プロセスの分析に有用であることが実証されています。当社は、Penicillium brefeldianumから単離した天然のブレフェルドンを提供しています。細胞をBFAに曝露すると、ERからゴルジ装置への細胞内タンパク質輸送が変形し、最終的にはゴルジ装置の形態が失われます詳細を見る

製品番号（カタログ番号）	数量
B7450	5 mg

製品番号（カタログ番号） B7450

価格（JPY）

31,800

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真菌代謝物ブレフェルジンA（BFA）は細胞内に複数の標的を有し、新たに合成されたタンパク質の核外輸送に関与する小胞形成やキナーゼ分布などの細胞プロセスの分析に有用であることが実証されています。当社は、Penicillium brefeldianumから単離した天然のブレフェルドンを提供しています。細胞をBFAに曝露すると、ERからゴルジ装置への細胞内タンパク質輸送が変形し、最終的にはゴルジ装置の形態が失われます。BFAを完全に除去すると、この効果は逆転します。BFAはエンドソームやリソソームの形態も変化させます。

研究用にのみ使用できます。診断用には使用いただけません。

標識タイプ非標識

分子式C₁₆H₂₄O₄

分子量280.36

数量5 mg

推奨保存方法フリーザー（-5℃～-30℃）に保存

出荷条件室温

物理的フォーム粉末

製品タイプスフィンゴ脂質

Unit SizeEach

引用および参考文献 (173)

引用および参考文献

Abstract

Nocodazole-dependent transport, and brefeldin A--sensitive processing and sorting, of newly synthesized membrane proteins in cultured neurons.

Authors:Cid-Arregui A, Parton RG, Simons K, Dotti CG

Journal:J Neurosci

PubMed ID:7790910

The envelope glycoproteins of Semliki Forest virus (SFV), Vesicular Stomatitis virus (VSV), and Influenza Fowl Plague virus (FPV) are vectorially targeted in neurons to the plasma membrane of dendrites (SFV and VSV) and axons (FPV). To gain insight into the mechanisms responsible for such polarized delivery we have examined the ... More

Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus.

Authors:Erickson JW, Zhang C, Kahn RA, Evans T, Cerione RA

Journal:J Biol Chem

PubMed ID:8900167

'In this study, we have used immunocytochemical and fractionation approaches to provide a description of the localization of the mammalian Cdc42 protein (designated Cdc42Hs) in vivo. A specific anti-peptide antibody was generated against the C-terminal region of Cdc42Hs. Using affinity-purified preparations of this antibody in indirect immunofluorescence experiments, Cdc42Hs was ... More

Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome.

Authors:Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ

Journal:Arthritis Rheum

PubMed ID:9324025

'OBJECTIVE: To identify a Golgi complex autoantigen bound by Sjögren''s syndrome (SS) autoantibodies. METHODS: Serum from a patient with secondary SS and anti-Golgi antibodies was used as a probe to isolate a complementary DNA (cDNA) insert from a HeLa cDNA library. RESULTS: A 3.7-kb cDNA encoding a 56-kd recombinant protein ... More

An ordered inheritance strategy for the Golgi apparatus: visualization of mitotic disassembly reveals a role for the mitotic spindle.

Authors:Shima DT, Cabrera-Poch N, Pepperkok R, Warren G

Journal:J Cell Biol

PubMed ID:9585414

'During mitosis, the ribbon of the Golgi apparatus is transformed into dispersed tubulo-vesicular membranes, proposed to facilitate stochastic inheritance of this low copy number organelle at cytokinesis. Here, we have analyzed the mitotic disassembly of the Golgi apparatus in living cells and provide evidence that inheritance is accomplished through an ... More

Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of shiga toxin B-fragment transport.

Authors:Mallard F, Antony C, Tenza D, Salamero J, Goud B, Johannes L

Journal:J Cell Biol

PubMed ID:9817755

'Shiga toxin and other toxins of this family can escape the endocytic pathway and reach the Golgi apparatus. To synchronize endosome to Golgi transport, Shiga toxin B-fragment was internalized into HeLa cells at low temperatures. Under these conditions, the protein partitioned away from markers destined for the late endocytic pathway ... More

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