Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers

Experience confident small-molecule and multi-omics analysis in complex samples. Accelerate insights across metabolomics, drug metabolism, and environmental research with Orbitrap Excedion MS, a versatile high-resolution accurate-mass platform that delivers high sensitivity, extended dynamic range with eDR, and sub-ppm mass accuracy. Orbitrap Excedion MS can be upgraded in-lab to Orbitrap Excedion Pro MS, expanding capabilities for advanced proteomics and biopharma research, including extended mass detection up to m/z 12,000 with optional fast and sensitive ETD/EThcD fragmentation.

Metabolomics

Orbitrap Excedion MS enables deep metabolomic profiling with high sensitivity, extended dynamic range (eDR), and HRAM performance. Fast polarity switching, nano-flow capabilities, and integrated Compound Discoverer workflows support broad coverage, including single-cell lipidomics.

Metabolite Identification (MetID)

For MetID, Orbitrap Excedion MS combines HRAM and eDR to detect low-abundance metabolites alongside parent compounds. Sub-ppm mass accuracy and integrated workflows with Thermo Scientific™ Compound Discoverer Software and Mass MetaSite™ enable confident annotation.

Environmental & Food Safety (EFS)

Orbitrap Excedion MS delivers sensitive EFS research analysis with enhanced MS¹sensitivity and eDR for trace-level detection. HRAM full-scan data supports confident suspect and non-target screening of PFAS and emerging contaminants.

BioPharma

Orbitrap Excedion BioPharma edition MS supports BioPharma analysis through a dedicated oligonucleotide mode with optimized pressure control, enabling intact mass, sequencing, and quantitative characterization of mRNA, oligonucleotides, and ADC-related species.

With in-lab upgrade to Orbitrap Excedion Pro BioPharma edition MS and optional fast and sensitive ETD fragmentation, users can expand biopharma and proteomics capabilities. Advanced fragmentation enables Asp/IsoAsp detection, Leu/Ile resolution, enhanced middle-down coverage, and near single-residue HDX-MS, supporting deep proteome, PTM, and immunopeptidomics analysis.