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Citations & References (33)
Invitrogen™
DiFMUP (6,8-Difluoro-4-Methylumbelliferyl Phosphate)
DiFMUPは、フッ化4-メチルウンベリフェリルリン酸（MUP）誘導体です。MUPよりも低いpKaを持つため、低pHでの酸性ホスファターゼの連続アッセイに適した基質です。DiFMUPの反応生成物の最大励起波長／最大発光波長は約358/450 nmです。また、10詳細を見る
製品番号（カタログ番号） D6567
価格（JPY）お問い合わせください ›
38,300
Each
数量:
5mg
DiFMUPは、フッ化4-メチルウンベリフェリルリン酸（MUP）誘導体です。MUPよりも低いpKaを持つため、低pHでの酸性ホスファターゼの連続アッセイに適した基質です。DiFMUPの反応生成物の最大励起波長／最大発光波長は約358/450 nmです。また、10 mgのバイアル10本にそれぞれ充填されたDiFMUP（D-22065）もご用意しています。
研究用にのみ使用できます。診断用には使用いただけません。
仕様
色青色
励起／発光358⁄455
使用対象 (装置)マイクロプレートリーダー
標識または色素DiFMU
数量5mg
出荷条件室温
基質ホスファターゼ基質
検出法蛍光
形状粉末
Substrate Properties化学基質
Target Enzymeホスファターゼ
Unit SizeEach
組成および保存条件
冷凍庫（-5～-30℃）に保存。
引用および参考文献 (33)
引用および参考文献
Abstract
Surface phosphophilicity of aluminum-containing adjuvants probed by their efficiency for catalyzing the P--O bond cleavage with chromogenic and fluorogenic substrates.
Journal:Anal Biochem
PubMed ID:11476547
'Aluminum-containing adjuvants are widely used in a variety of vaccine products, such as recombinant proteins, virus-like particles, conjugated polysaccharides, and recently DNA vaccines. Aluminum-containing adjuvants are also known to have a high affinity to inorganic phosphate and its mono- or diesters. Since phosphate groups are present in many antigens as
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
Journal:Nat Cell Biol
PubMed ID:15592458
'Integrin-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signalling pathways. So far, integrins have been mainly shown to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signalling. Here we show that a collagen-binding integrin alpha(1)beta(1) functions as a negative regulator of
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Journal:Mol Pharmacol
PubMed ID:16717135
'Shp2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. It is involved in growth factorinduced activation of mitogen-activated protein (MAP) kinases Erk1 and Erk2 (Erk1/2) and has been implicated in the pathogenicity of the oncogenic bacterium Helicobacter pylori. Moreover, gain-of-function Shp2 mutations have been found in
Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects.
Journal:J Cell Biochem
PubMed ID:16514605
'PTP69D is a receptor protein tyrosine phosphatase that was identified as a key regulator of neuromuscular axon guidance in Drosophila, and has subsequently been shown to play a similar role in the central nervous system and retina. Three Ptp69D alleles with mutations involving catalytically important residues exhibit a high degree
High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors.
Journal:Assay Drug Dev Technol
PubMed ID:17939754
'Protein phosphatase type 5 (PP5) belongs to the PPP family of serine/threonine protein phosphatases and is expressed in most, if not all, human tissues. Although the physiological roles played by PP5 are not yet clear, PP5 is found in association with several proteins that influence intracellular signaling networks initiated by