BODIPY™ FL C12-Sphingomyelin (N-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoyl) Sphingosyl Phosphocholine)
BODIPY&trade; FL C<sub>12</sub>-Sphingomyelin (<i>N</i>-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-<i>s</i>-Indacene-3-Dodecanoyl) Sphingosyl Phosphocholine)
Citations & References (24)
Invitrogen™

BODIPY™ FL C12-Sphingomyelin (N-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoyl) Sphingosyl Phosphocholine)

緑色蛍光を示すスフィンゴミエリンであるBODIPY™ FL C12-スフィンゴミエリンは、細胞内のスフィンゴ脂質の輸送およびシグナル伝達経路の研究に使用できます。詳細を見る
テクニカルサポートオーダーサポート
製品番号（カタログ番号）数量
D7711250 μL
製品番号（カタログ番号） D7711
価格（JPY）
52,000
Online offer
Ends: 27-Mar-2026
86,700
割引額 34,700 (40%)
Each
お問い合わせください ›
数量:
250 μL
緑色蛍光を示すスフィンゴミエリンであるBODIPY™ FL C12-スフィンゴミエリンは、細胞内のスフィンゴ脂質の輸送およびシグナル伝達経路の研究に使用できます。
研究用にのみ使用できます。診断用には使用いただけません。
仕様
化学物質名または材質Sphingolipids
推奨保存方法Store in freezer (-5 to -30°C) and protect from light.
製品ラインBODIPY
数量250 μL
Unit SizeEach

引用および参考文献 (24)

引用および参考文献
Abstract
Fluorescence-based selection of gene-corrected hematopoietic stem and progenitor cells from acid sphingomyelinase-deficient mice: implications for Niemann-Pick disease gene therapy and the development of improved stem cell gene transfer procedures.
Authors:Erlich S, Miranda SR, Visser JW, Dagan A, Gatt S, Schuchman EH
Journal:Blood
PubMed ID:9864149
'The general utility of a novel, fluorescence-based procedure for assessing gene transfer and expression has been demonstrated using hematopoietic stem and progenitor cells. Lineage-depleted hematopoietic cells were isolated from the bone marrow or fetal livers of acid sphingomyelinase-deficient mice, and retrovirally transduced with amphotropic or ecotropic vectors encoding a normal ... More
gamma-cyclodextrins greatly enhance translocation of hydrophobic fluorescent phospholipids from vesicles to cells in culture. Importance of molecular hydrophobicity in phospholipid trafficking studies.
Authors:Tanhuanpää K, Somerharju P
Journal:J Biol Chem
PubMed ID:10585403
'Short-chain, fluorescent derivatives are commonly used to investigate intracellular phospholipid trafficking. However, their use can yield misleading results because they, unlike the native species, can rapidly distribute between organelles due to their low hydrophobicity. On the other hand, hydrophobic derivatives are very difficult to introduce to cells and thus have ... More
A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways.
Authors:Steinert S, Lee E, Tresset G, Zhang D, Hortsch R, Wetzel R, Hebbar S, Sundram JR, Kesavapany S, Boschke E, Kraut R,
Journal:PLoS ONE
PubMed ID:18716682
'BACKGROUND: The uptake and intracellular trafficking of sphingolipids, which self-associate into plasma membrane microdomains, is associated with many pathological conditions, including viral and toxin infection, lipid storage disease, and neurodegenerative disease. However, the means available to label the trafficking pathways of sphingolipids in live cells are extremely limited. In order ... More
A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease.
Authors:He X, Chen F, Dagan A, Gatt S, Schuchman EH
Journal:Anal Biochem
PubMed ID:12633609
'Acid sphingomyelinase (ASM; sphingomyelin phosphodiesterase, EC 3.1.4.12) is the lysosomal enzyme that hydrolyzes sphingomyelin (SPM) to phosphorylcholine and ceramide. An inherited deficiency of ASM activity results in Types A and B Niemann-Pick disease (NPD). In this study we report a new assay method to detect ASM activity and diagnose NPD ... More
Synthesis of fluorescent substrates and their application to study of sphingolipid metabolism in vitro and in intact cells.
Authors:Dagan A, Agmon V, Gatt S, Dinur T
Journal:Methods Enzymol
PubMed ID:11070879
View all BODIPY™ FL C12-Sphingomyelin (N-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoyl) Sphingosyl Phosphocholine) citations