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引用および参考文献 (20)
引用および参考文献
Abstract
Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides.
Authors:Xu J, Liu D, Gill G, Songyang Z
Journal:J Cell Biol
PubMed ID:11514587
'PKB/Akt and serum and glucocorticoid-regulated kinase (SGK) family kinases are important downstream targets of phosphatidylinositol 3 (PI-3) kinase and have been shown to mediate a variety of cellular processes, including cell growth and survival. Although regulation of Akt can be achieved through several mechanisms, including its phosphoinositide-binding Pleckstrin homology (PH) ... More
The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system.
Authors:Angers A, Ramjaun AR, McPherson PS
Journal:J Biol Chem
PubMed ID:14684745
'Endophilin A1 is an SH3 domain-containing protein functioning in membrane trafficking on the endocytic pathway. We have identified the E3 ubiquitin ligase itch/AIP4 as an endophilin A1-binding partner. Itch belongs to the Nedd4/Rsp5p family of proteins and contains an N-terminal C2 domain, four WW domains and a catalytic HECT domain. ... More
Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells.
Authors:Sonee M, Barrón E, Yarber FA, Hamm-Alvarez SF
Journal:Am J Physiol
PubMed ID:9843725
'Although taxol inhibits membrane trafficking, the nature of this inhibition has not been well defined. In this study, we define the effects of taxol on endocytosis in CV-1 cells using density gradient centrifugation of membranes over sorbitol density gradients. After taxol treatment, resident endosomal enzymes and the epidermal growth factor ... More
Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis.
'We previously identified intersectin, a multiple EH and SH3 domain-containing protein, as a component of the endocytic machinery. Overexpression of the SH3 domains of intersectin blocks transferrin receptor endocytosis, possibly by disrupting targeting of accessory proteins of clathrin-coated pit formation. More recently, we identified mammalian Sos, a guanine-nucleotide exchange factor ... More
Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes.
Authors:Krauss M, Kukhtina V, Pechstein A, Haucke V
Journal:Proc Natl Acad Sci U S A
PubMed ID:16880396
'Phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] is an important factor for a variety of cellular functions ranging from cell signaling to actin cytoskeletal dynamics and endocytic membrane traffic. Here, we have identified the clathrin adaptor complex AP-2 as a regulator of phosphatidylinositol 4-phosphate 5-kinase (PIPK)-mediated PI(4,5)P(2) synthesis. AP-2 directly interacts with the kinase ... More