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Thermo Scientific Chemicals
N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-Hydroxysuccinimide
CAS: 74124-79-1 | C9H8N2O7 | 256.17 g/mol
化学物質識別子
CAS74124-79-1
IUPAC Namebis(2,5-dioxopyrrolidin-1-yl) carbonate
Molecular FormulaC9H8N2O7
InChI KeyPFYXSUNOLOJMDX-UHFFFAOYSA-N
SMILESO=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O
さらに表示
仕様
スペックシート
スペックシートAppearance (Color)White to pale cream
FormPowder or crystalline powder
Assay (HPLC)(N-Hydroxysuccinimide derivatives) : ≥99.0%
Identification (FTIR)Conforms
N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
N,N′-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.
Solubility
Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.
Notes
Moisture sensitive. Store in a cool place. Incompatible with strong acids and oxidizing agents.
N,N′-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.
Solubility
Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.
Notes
Moisture sensitive. Store in a cool place. Incompatible with strong acids and oxidizing agents.
RUO – Research Use Only
General References:
- Černoch, P.; Černochová, Z.; Kučka, J.; Hrubý, M.; Petrova, S.; Štěpánek, P. Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications. Appl. Radiat. Isot. 2015, 98, 7-12.
- Nale, D. B.; Bhanage, B. M. Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction. Green Chem. 2015, 17 (4), 2480-2486.