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Thermo Scientific Chemicals
N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%, Thermo Scientific Chemicals
| 製品番号（カタログ番号） | 数量 |
|---|---|
| H54144.06 または、製品番号H54144-06 | 5 g |
化学物質識別子
CAS125700-69-8
IUPAC Name[(dimethylamino)[(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)oxy]methylidene]dimethylazanium; tetrafluoroboranuide
Molecular FormulaC12H16BF4N5O2
InChI KeyFOBCPCIJLQTYBT-UHFFFAOYSA-N
SMILESF[B-](F)(F)F.CN(C)C(ON1N=NC2=CC=CC=C2C1=O)=[N+](C)C
さらに表示
仕様
スペックシート
スペックシートAssay (HPLC)>98.0%
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N?,N?-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.
Solubility
Soluble in acetonitrile 0.1 g/mL.
Notes
Moisture and light sensitive. Store away from water/ moisture, oxidizing agents. Protect from heat.
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.
Solubility
Soluble in acetonitrile 0.1 g/mL.
Notes
Moisture and light sensitive. Store away from water/ moisture, oxidizing agents. Protect from heat.
RUO – Research Use Only
General References:
- J Hiebl, D P Alberts; A F Banyard; K Baresch; H Baumgartner; I Bernwieser; P K Bhatnagar; M Blanka; M Bodenteich; T Chen; P M Esch; H Kollmann; I Lantos; K Leitner; G Mayrhofer; R Patel; A Rio; F Rovenszky; D Stevenson; K D Tubman; K Undheim; H Weihtrager; W Welz; K Winkler. Large-scale synthesis of hematoregulatory nonapeptide SK&F 107647 by fragment coupling. Journal of Peptide Research. 1999, 54 (1), 54-65.
- Cuihua Liu; Hudson Robert H. E.; Petersen Nils O. Convergent and sequential synthesis of dendritic, multivalent complexing agents. Synthesis. 2002, (10), 1398-1406.