Ionomycin, Calcium Salt

Citations & References (75)

Invitrogen™

Ionomycin, Calcium Salt

イオノマイシンは、効果的なCa2+イオノフォアで、細胞内Ca2+濃度を変更し、細胞プロセスにおけるCa2+の調節特性を研究する際に蛍光Ca2+インジケータを校正するために一般的に使用されています。また、イオノマイシンは、Pb2+とその他の二価陽イオン、および複数のランタノイド系三価陽イオンを Ca2+と同等以上の効率で輸送します。カルシウム詳細を見る

製品番号（カタログ番号）	数量
I24222	1 mg

製品番号（カタログ番号） I24222

価格（JPY）

39,100

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イオノマイシンは、効果的なCa²⁺イオノフォアで、細胞内Ca²⁺濃度を変更し、細胞プロセスにおけるCa²⁺の調節特性を研究する際に蛍光Ca²⁺インジケータを校正するために一般的に使用されています。また、イオノマイシンは、Pb²⁺とその他の二価陽イオン、および複数のランタノイド系三価陽イオンを　Ca²⁺と同等以上の効率で輸送します。

カルシウム、カリウム、pH、膜電位インジケータなどのイオンインジケータの詳細については、こちらを参照してください›

研究用にのみ使用できます。診断用には使用いただけません。

インジケーターイオノフォア

分子式C₄₁H₇₀CaO₉

分子量747.08

数量1 mg

推奨保存方法フリーザー（-5℃～-30℃）に保存

出荷条件室温

物理的フォームSolid

製品タイプカルシウム塩

Unit SizeEach

引用および参考文献 (75)

引用および参考文献

Abstract

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.

Authors:Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM

Journal:J Clin Invest

PubMed ID:11748270

'Atopic diseases such as allergy and asthma are characterized by increases in Th2 cells and serum IgE antibodies. The binding of allergens to IgE on mast cells triggers the release of several mediators, of which histamine is the most prevalent. Here we show that histamine, together with a maturation signal, ... More

Recombinant expression of the plasma membrane Na(+)/Ca(2+) exchanger affects local and global Ca(2+) homeostasis in Chinese hamster ovary cells.

Authors:Brini M, Manni S, Carafoli E

Journal:J Biol Chem

PubMed ID:12145298

'The cardiac type Na(+)/Ca(2+) exchanger (NCX1) has been transiently expressed in Chinese hamster ovary cells, which do not contain an endogenous exchanger, together with aequorin chimeras that are targeted to different intracellular compartments to investigate intracellular Ca(2+) homeostasis. The expression of NCX decreased the endoplasmic reticulum Ca(2+) concentration, [Ca(2+)](er), in ... More

Signaling alterations in activation-induced nonresponsive CD8 T cells.

Authors:Tham EL, Mescher MF

Journal:J Immunol

PubMed ID:11489986

'Costimulation-dependent production and autocrine use of IL-2 by activated CD8 T cells results in initial clonal expansion, but this is transient. The cells quickly become anergic, unable to produce IL-2 in response to Ag and costimulation, irrespective of the form of costimulation. This activation-induced non-responsiveness (AINR) differs from "classical" anergy ... More

Phosphatidylinositol 3-kinase-dependent extracellular calcium influx is essential for CX(3)CR1-mediated activation of the mitogen-activated protein kinase cascade.

Authors:Kansra V, Groves C, Gutierrez-Ramos JC, Polakiewicz RD

Journal:J Biol Chem

PubMed ID:11432847

'Fractalkine, the first member of the CX(3)C chemokine family, induces leukocyte chemotaxis through activation of its high affinity receptor, CX(3)CR1. Like other chemokine receptors, CX(3)CR1 is coupled to a pertussis toxin-sensitive heterotrimeric G(i) protein, which is necessary for rapid rise in the concentration of intracellular calcium. Using a Chinese hamster ... More

Differences in regulation between nuclear and cytoplasmic Ca2+ in cultured smooth muscle cells.

Authors:Himpens B, De Smedt H, Droogmans G, Casteels R

Journal:Am J Physiol

PubMed ID:1386189

'The free Ca2+ concentrations in the nucleus ([Ca2+]n) and cytoplasm ([Ca2+]c) of cultured smooth muscle cells were estimated using the fluorescent dye indo-1 and the ACAS 570 confocal laser microscope. In resting DDT1MF2 smooth muscle cells [Ca2+]n was found to be lower than [Ca2+]c. Both values increased transiently in response ... More

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