Doxycycline hyclate

Name: Doxycycline hyclate
SKU: J60579.14

Doxycycline hyclate, Doryx, CAS # 24390-14-5, is the hyclate salt form of the broad-spectrum antibiotic known as doxycycline. | CAS: 24390-14-5 | C26H41ClN2O12 | 609.066 g/mol

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数量:

25 g

100 g

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製品番号（カタログ番号） J60579.14

または、製品番号J60579-14

価格（JPY）

数量:

25 g

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化学物質識別子

CAS24390-14-5

IUPAC Namedihydrogen bis((2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione) ethanol hydrate dichloride

Molecular FormulaC46H58Cl2N4O18

InChI KeyQDDHZFKCHWYXJF-PCLMCNLLSA-N

SMILES[H+].[H+].O.[Cl-].[Cl-].CCO.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12

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仕様

スペックシート

FormPowder or crystals or crystalline powder

Assay from Suppliers CofAReport assay (%) or potency (µg/mg)

pH2.0-3.0

Appearance (Color)Yellow

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General description
• Doxycycline hyclate is a broad-spectrum bacteriostatic antibiotic of the tetracycline class
• Doxycycline inhibits bacterial growth by preventing polypeptide formation via inhibition of at least one ribosomal subunit
• Known to reversibly bind the 30S ribosomal subunit and inhibit formation of the aminoacyl-tRNA/mRNA-ribosome complex
• Inhibits matrix metalloproteinases in many microorganisms
Applications
• Effective against the bacteria that cause Lyme disease, chlamydia, rickettsia and mycoplasma; suitable for antibiotic resistance testing and study of cellular mechanisms
• Intended for laboratory use only

RUO – Research Use Only

General References:

Adrian, J.; Fernández, F.; Sánchez-Baeza, F.; Marco, M. P. Preparation of antibodies and development of an enzyme-linked immunosorbent assay (ELISA) for the determination of doxycycline antibiotic in milk samples. J Agric Food Chem. 2012, 60(15), 3837-46.
Aleksic, T.; Baumann, B., Wagner, M.; Adler, G.; Wirth, T.; Weber, C. K. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut. 2007, 56(2), 227-36.
Moore, A. L.; desJardins-Park, H. E.; Duoto, B. A.; Mascharak, S.; Murphy, M. P.; Irizarry, D. M.; Foster, D. S.; Jones, R. E.; Barnes, L. A.; Marshall, C. D; Ransom, R. C.; Wernig, G.; Longaker, M. T. Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg. 2020, 272(1),183-193.
Doxycycline host-directed therapy in human pulmonary tuberculosis.
Miow Q. H.; Vallejo A. F.; Wang Y; Hong J. M.; Bai C., Teo F. S.; Wang A. D.; Loh H. R.; Tan T. Z.; Ding Y., She H. W.; Gan S. H.; Paton N. I.; Lum J.; Tay A.; Chee C. B.; Tambyah P. A.; Polak M. E.; Wang Y. T.; Singhal A.; Elkington P. T.; Friedland J. S.; Ong C. W. J Clin Invest. 2021 Aug 2;131(15):e141895. doi: 10.1172/JCI141895.