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Thermo Scientific Chemicals
2'-Deoxyguanosine monohydrate, 98+%
CAS: 961-07-9 | C10H13N5O4 | 267.25 g/mol
化学物質識別子
CAS961-07-9
IUPAC Name2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
Molecular FormulaC10H13N5O4
InChI KeyYKBGVTZYEHREMT-DWFKHXNSNA-N
SMILESNC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1
さらに表示
仕様
スペックシート
スペックシートIdentification (FTIR)Conforms to standard
Appearance (Color)White to off-white
Assay (HPLC)≥98.0%
Water Content (Karl Fischer Titration)8.0% max
FormCrystalline powder
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
Solubility
Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
Solubility
Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Kasper Broedbaek et. al. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes. Free Radical Biology and Medicine. 2011, 51 (8), 1473-1479.
- Aaron M Fleming et. al. Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts.. Journal of Organic Chemistry. 2011, 76 (19), 7953-7963.