Colistin sulfate

Colistin Sulfate salt (2:5), CAS # 1264-72-8, (synonym: Polymyxin E Complex), is a complex mixture of antibiotics, with Colistin A and B being the primary components. It has anti-bacterial activity against Gram-positive and Gram-negative bacteria and may also be used as a neuromuscular blocker. | CAS: 1264-72-8

製品番号（カタログ番号）	数量
J60915.03 または、製品番号J60915-03	1 g

製品番号（カタログ番号） J60915.03

または、製品番号J60915-03

価格（JPY）

一括またはカスタム形式をリクエストする

化学物質識別子

CAS1264-72-8

IUPAC NameN-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide; sulfuric acid

Molecular FormulaC53H102N16O17S

InChI KeyZJIWRHLZXQPFAD-LRYSGCCDSA-N

SMILESOS(O)(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O

さらに表示

Potency≥19000 IU/mg (dried basis)

FormPowder

Appearance (Color)White to pale cream

pH4.0-6.0

Solution TestClear and light yellow solution (50 mg/ml in H2O)

さらに表示

Colistin sulfate A Polymyxin potent antibiotic and apoptosis inducer. This compound induces apoptosis through interaction with the cytoplasmic membrane. Colistin is a key microbiological component in Colistin Oxolinic Acid Blood Agar utilized in the cultivation of Aminobacter aminovorans, Bacillus species, Hyphomicrobium species and Methylobacterium species. It is also a critical component is VCN Inhibitor & VCNT Inhibitor growth media used in the isolation of Neisseria species.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Colistin Sulfate salt is a stable, cationic, water-soluble, white powder composed of over 30 components
Originally isolated from B. polymyxa, it inhibits the growth of the Gram-negative (e.g. E. coli, P. aeruginosa, P. fluorescens, and S. enterica), and Gram-positive bacteria (e.g. L. lactis, P. polymyxa, P. acidilactici, and S. aureus) by permeabilizing the bacterial cell membrane

Applications

Colistin Sulfate has potent anti-endotoxin activity rendered through its ability to bind lippopolysaccharides that make up bacterial endotoxins
This compound is often used in the management of multi-drug resistant Gram-negative infections

RUO – Research Use Only

General References:

ME Falagas.; SK Kasiakou. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005, 40 ,(9), 1333-1341.
BP Kelleher.; KG Walshe.; JM Scott. Microbiological assay for vitamin B12 with use of a colistin-sulfate-resistant organism. Clinical Chemistry. 1987, 33 ,(1), 52-54.
Falagas, M. E.; Kasiakou, S. K.; Saravolatz, L. D. Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections Clinical Infectious Diseases. 2005, 40 (9), 1333–1341.
Suzuki, T.; Inouye, H.; Fujikawa, K.; et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 1963, 54(1), 25-33.
Naghmouchi, K.; Hammami, R.; Fliss, I.; et al. Colistin A and colistin B among inhibitory substances of Paenibacillus polymyxa JB05-01-1. Arch. Microbiol. 2012, 194(5), 363-370.
Mitsugui, C.S.; Tognim, M.C.B.; Cardoso, C.L.; et al. In vitro activity of polymyxins in combination with β-lactams against clinical strains of Pseudomonas aeruginosa. Int. J. Antimicrob. 2011, 38(5), 447-450.